Mineralocorticoid Receptors Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell
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چکیده
Dafina Pruthi, Amy McCurley, Mark Aronovitz, Carol Galayda, S. Ananth Karumanchi and Iris Mineralocorticoid Receptors Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2013 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.113.302854 2013; 2014;34:355-364; originally published online December 5, Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/34/2/355 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://atvb.ahajournals.org/content/suppl/2013/12/05/ATVBAHA.113.302854.DC1.html Data Supplement (unedited) at:
منابع مشابه
Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors.
OBJECTIVE Vascular remodeling occurs after endothelial injury, resulting in smooth muscle cell (SMC) proliferation and vascular fibrosis. We previously demonstrated that the blood pressure-regulating hormone aldosterone enhances vascular remodeling in mice at sites of endothelial injury in a placental growth factor-dependent manner. We now test the hypothesis that SMC mineralocorticoid receptor...
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Mineralocorticoids have been suggested to act on blood vessels, leading to increased vasoreactivity and peripheral resistance. However, the site of their production has so far been believed to be only the adrenal cortex. Here, we show direct evidence that vascular cells per se are aldosteronogenic, possessing their own system that responds to the steroid. Using polymerase chain reaction after r...
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OBJECTIVE Clinical studies demonstrate that mineralocorticoid receptor (MR) antagonism improves outcomes in cardiovascular patients and that vascular calcification correlates with adverse cardiac events. We have recently demonstrated that human vascular smooth muscle cells (VSMCs) express functional MRs that, in response to aldosterone, modulate expression of osteogenic genes including alkaline...
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BACKGROUND The novel nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone holds promise to be safe and efficient in the treatment of patients with heart failure and/or chronic kidney disease. However, its effects on vascular function remain elusive. PURPOSE The aim of this study was to determine the functional effect of selective MR antagonism by finerenone in vascular cells in ...
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